School of Biological Sciences
Georgia Institute of Technology
I am working on finding new drug leads from marine ecosystems. My research is guided by chemical ecology information gathered from the study of Coral reef in South Pacific. Indeed, the chemical cue used by marine organisms have evolved in such a way that they are perfectly adapted to interact with receptors. These diverse chemical compounds are thus well suited for drug screening. The strategy I use is bioassay-guided fractionation, which include all type of chromatography, nuclear magnetic resonance, mass spectrometry, circular dichroism spectroscopy. In some occasion, I use computer modeling to facilitate the analysis of the different spectra of a molecule.
Publications (to view a full list of publications, click here)
Simard, F.; Gauthier, C.; Chiasson, É.; Lavoie, S.; Mshvildadze, V.; Legault, J.; Pichette, A. (2015) Antibacterial Balsacones J−M, Hydroxycinnamoylated Dihydrochalcones from Populus balsamifera Buds. Journal of Natural Products, 78: 1147-1153.
Lavoie, S.; Gauthier, C.; Legault, J.; Mercier, S.; Mshvildadze, V.; Pichette, A. (2013) Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin. Beilstein Journal of Organic Chemistry, 9: 1333-1339.
Lavoie, S.; Legault, J.; Gauthier, C.; Mshvildadze, V., Mercier, S.; Pichette, A. (2012) Abibalsamins A and B, two new tetraterpenoids from Abies balsamea oleoresin. Organic Letters, 14: 1504-1507. Contribution highlighted in Natural Product Reports – Hot off the Press 2012, 19, 617-621